Big Top

A screwball set of characters including a poodle/pop-star wannabe with a chapstick addiction, a trick bear with a crush on Katie Couric bordering on unhealthy, a clown demented beyond description, and a 10-year-old boy growing up in a circus and trying not to wind up too damaged in the process. Unfortunately, the creator Rob Harrell stopped writing the strip in 2007, but the reruns are still posted on GoComics' site daily. My favorite character is Stucco the clown, who manages with no dialog to be the ultimate combination of cute and creepy you'd expect in a proper clown.
Dog Eat Doug
Alternatively, we have Dog Eat Doug, which explores the antics of Sophie the dog and Doug the baby, two completely typical creatures trying to learn to co-exist to each other's advantage. There is no snark here, no cynicism. This is just the demonstration of how two non-verbal creatures find ways to communicate. That's not to say the strip doesn't have dialog - Sophie thinks at Doug, mom, and dad all the time. It's just you know mom and dad don't understand - and Doug does when he chooses to. Lock up the cheese, and prepare for significant drool!

And of course, everyone's favorite Calvin & Hobbes. I don't need to wax eloquent here. I merely mention it to put a button on the end of this post:

I know, Calvin. I feel the same way sometimes.